منابع مشابه
Association of TAP1 and TAP2 gene polymorphisms with hematological malignancies.
Transporter associated with antigen presenting (TAP) 1 and TAP2 genes are localized in the major histocompatability complex (MHC) class II region and form a heterodimer playing a key role in endogenous pathways for antigen presentation. Defects of these genes have been reported to be common in different types of cancer. Polymorphisms identified in these loci have also been investigated and repo...
متن کاملPolymorphisms of the TAP2 transporter gene in systemic lupus erythematosus.
OBJECTIVES To determine whether the TAP2 transporter gene, which lies between HLA-DP and HLA-DQ, is involved in determining susceptibility to systemic lupus erythematosus (SLE). METHODS TAP2 types were determined by ARMS-PCR in 89 white patients with SLE and 156 control subjects. RESULTS No particular TAP2 dimorphism or allele was associated with SLE or with any clinical/immunological subgr...
متن کاملAssociation of TAP1 and TAP2 Gene Polymorphisms with Susceptibility to Pulmonary Tuberculosis.
TAP1 and TAP2 genes encode heterodimeric molecule involved in endogenous antigen processing. The present study was undertaken to find out the possible association between TAP1 and TAP2 polymorphisms and risk of pulmonary tuberculosis (PTB) in a sample of Iranian population. Polymorphisms of TAP1 (rs1057141, rs1135216) and TAP2 (rs2228396, rs241447, rs67511411, rs141555015) were determined in 17...
متن کاملCONCISE REPORT TAP1 and TAP2 polymorphisms analysis in northwestern Colombian patients with systemic lupus erythematosus
Objective: To determine the influence of TAP1 and TAP2 alleles in northwestern Colombian patients with systemic lupus erythematosus (SLE). Methods: Unselected patients with SLE (n=140) and controls (n=120) matched for sex, age, and ethnicity were analysed. Clinical manifestations, clinical activity, and severity of disease were recorded. Autoantibodies were detected by enzyme linked immunosorbe...
متن کاملTAP1 and TAP2 Gene Polymorphisms in Korean Patients with Allergic Rhinitis
Antigen peptides are actively transported across the endoplasmic reticulum by the transporters associated with antigen presentation (TAP). TAP genes polymorphism could influence the selection process that determines which antigen peptides play a role in the pathogenesis of allergic rhinitis. The aim of this study was to investigate the association of TAP genes polymorphism with allergic rhiniti...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1996
ISSN: 0003-4967
DOI: 10.1136/ard.55.12.924